Vértessy G.
Beáta MTA bemutatkozás
Kiemelt 4 közlemény (az adott közlemény a címre kattintva nyílik meg)
1. Vértessy BG. Flexible glycine rich motif of
Escherichia coli deoxyuridine triphosphate nucleotidohydrolase is important for
functional but not for structural integrity of the enzyme. Proteins. 1997 Aug;28(4):568-79.
2. Barabás O, Pongrácz V, Kovári J, Wilmanns M, Vértessy BG. Structural insights into the
catalytic mechanism of phosphate ester hydrolysis by dUTPase. J Biol
Chem. 2004 Oct 8;279(41):42907-15.
3. Muha V, Horváth A, Békési A, Pukáncsik M,
Hodoscsek B, Merényi G, Róna G, Batki J, Kiss I, Jankovics F, Vilmos P, Erdélyi
M, Vértessy BG. Uracil-containing DNA in
Drosophila: stability, stage-specific accumulation, and developmental
involvement. PLoS Genet. 2012;8(6):e1002738.
4. Róna G, Marfori M, Borsos M, Scheer I, Takács E, Tóth J, Babos F,
Magyar A, Erdei A, Bozóky Z, Buday L, Kobe B,
Vértessy BG. Phosphorylation adjacent to the
nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic
insights. Acta Crystallogr D Biol Crystallogr. 2013 Dec; 69
(Pt 12):2495-505.
Kiegészítő dokumentáció MTA levelező tagjelölti ajánláshoz
Vértessy G. Beáta
Hazai,
önállóan végzett kutatásaimban vagy hazai saját kutatócsoportom keretében,
korábbi mentoromtól/témavezetőmtől függetlenül született olyan cikkeim száma,
amelyekben első vagy utolsó és/vagy levelező szerző vagyok:
86 cikk, ebből 78-ban eredeti in extenso,
kísérletes munkákból született eredményeket közöltem, összesen 7 review és 1
“response” cikk van köztük.
Ebből kiemelt presztízsű D1-es folyóiratban megjelent
publikáció: 37 (ezeket alább vastag
betűvel emeltem ki)
A
cikkeket ebben a dokumentumban fel is
sorolom. Ezek a cikkek korábbi témavezetőimtől függetlenül születtek, amit a
szerzőlista áttekintésével és korábbi témavezetőim (ld. alábbi felsorolás)
ismeretében lehet igazolni.
Szakmai pályafutásom során témavezetőim, mentoraim voltak a következő kutatók:
Dr
Keleti Tamás (MTA Enzimológiai Intézet) – MTA TMB ösztöndíjas időszakom alatti
témavezetőm, MTA kandidátusi disszertációm irányítója
1984-1989 között
Kazinczyné
Dr. Vas Mária (MTA Enzimológiai Intézet) – témavezetőm egyetemi éveim alatt
végzett TDK munkám során (1982-1984), továbbá rész-témavezetőm MTA TMB
ösztöndíjas időszakom alatt (1984-1986)
Dr.
Theodore Steck (University of Chicago) – témavezetőm a Univ
Chicagon töltött 1986-87 tanév során
Dr.
Ovádi Judit (MTA Enzimológiai Intézet– rész-témavezetőm MTA TMB ösztöndíjas
időszakom alatt (1987-1989), továbbá témavezetőm hazai posztdoktori éveim alatt
1991-1992, 1994-1998 között
Dr.
Michael Zeppezauer (Universitat Saarlandes) – témavezetőm 1992-1994 között
(Alexander von Humboldt posztdoktori időszakom alatt)
Cikkek listája (hazai,
önállóan végzett kutatásaimban vagy hazai saját kutatócsoportom keretében,
korábbi mentoromtól/témavezetőmtől függetlenül született olyan cikkeim,
amelyekben első vagy utolsó és/vagy levelező szerző vagyok):
86. Bata, Z; Molnár, Z; Madaras, E; Molnár, B; Sánta-Bell,
E; Varga, A; Leveles, I; Qian, R; Hammerschmidt,
F; Paizs, C*.; Vértessy, BG*.; Poppe, L*. (* corr author)
Substrate Tunnel Engineering Aided by X-ray Crystallography
and Functional Dynamics Swaps the Function of MIO-Enzymes
ACS CATALYSIS 11 : 8
pp. 4538-4549. , 12 p. (2021)
85. Pálinkás HL, Békési A,
Róna G, Pongor L, Papp G, Tihanyi G, Holub E, Póti Á, Gemma C, Ali S, Morten
MJ, Rothenberg E, Pagano M, Szűts D, Győrffy B, Vértessy BG.
Genome-wide alterations of uracil distribution patterns in
human DNA upon chemotherapeutic treatments.
ELIFE. 2020 SEP 21;9:E60498.
DOI: 10.7554/ELIFE.60498.
84.
REVIEW: Békési A, Holub E, Pálinkás HL, Vértessy
BG.
Detection
of Genomic Uracil Patterns.
INT
J MOL SCI. 2021 APR 9;22(8):3902.
83.
REVIEW: Nagy KK, Skurnik M, Vértessy BG.
Viruses
with U-DNA: New Avenues for Biotechnology.
VIRUSES.
2021 MAY 10;13(5):875.
82: Izrael R, Marton L, Nagy GN, Pálinkás HL, Kucsma N,
Vértessy BG
Identification of a nuclear localization signal in the
Plasmodium falciparum CTP: phosphocholine cytidylyltransferase enzyme.
SCI REP. 2020 NOV 12;10(1):19739.
81: Molnár P, Orbán Á, Izrael R, Babai R, Marton L, Butykai
Á, Karl S, Vértessy BG*,
Kézsmárki I. * (* corr authors)
Rapid and quantitative antimalarial drug efficacy testing
via the magneto-optical detection of hemozoin.
Sci Rep. 2020 Aug 20;10(1):14025.
80: REVIEW: Nyíri K, Koppány G, Vértessy BG.
Structure-based inhibitor design of mutant RAS proteins-a
paradigm shift.
CANCER METASTASIS REV. 2020 DEC;39(4):1091-1105
79:
Lopata A, Jójárt B, Surányi ÉV, Takács E, Bezúr
L, Leveles I, Bendes ÁÁ, Viskolcz B,
Vértessy
BG*, Tóth J. * (* corr authors)
Beyond
Chelation: EDTA Tightly Binds Taq DNA Polymerase, MutT and dUTPase and Directly
Inhibits dNTPase Activity.
BIOMOLECULES.
2019 OCT 17;9(10). PII: E621
78:
Nyíri K, Harris MJ, Matejka J, Ozohanics O, Vékey K, Borysik AJ, Vértessy BG.
HDX
and Native Mass Spectrometry Reveals the Different Structural Basis for
Interaction of the Staphylococcal Pathogenicity Island Repressor Stl with
Dimeric and Trimeric Phage dUTPases. BIOMOLECULES. 2019 SEP 14;9(9). PII: E488
77:
Benedek A, Temesváry-Kis F, Khatanbaatar T,
Leveles I, Surányi ÉV, Szabó JE, Wunderlich L, Vértessy BG.
The
Role of a Key Amino Acid Position in Species-Specific Proteinaceous dUTPase
Inhibition. BIOMOLECULES. 2019 JUN 6;9(6). PII: E221
76:
Rácz GA, Nagy N, Gál Z, Pintér T, Hiripi L, Vértessy BG.
Evaluation
of critical design parameters for RT-qPCR-based analysis of multiple dUTPase
isoform
genes
in mice.
FEBS
OPEN BIO. 2019 JUN;9(6):1153-1170.
75:
Pálinkás HL, Rácz GA, Gál Z, Hoffmann OI, Tihanyi G, Róna G, Gócza E, Hiripi L,
Vértessy BG.
CRISPR/Cas9-Mediated
Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality.
BIOMOLECULES. 2019 APR 4;9(4). PII: E136.
74:
Papp-Kádár V, Balázs Z, Vékey K, Ozohanics O, Vértessy BG.
Mass
spectrometry-based analysis of macromolecular complexes of Staphylococcus
aureus uracil-DNA glycosylase and its inhibitor reveals specific variations due
to naturally occurring mutations.
FEBS
OPEN BIO. 2019 FEB 9;9(3):420-427.
73: Nyiri K, Mertens HDT, Tihanyi B, Nagy GN, Kohegyi B,
Matejka J, Harris MJ, Szabo JE, Papp-Kadar V, Nemeth-Pongracz V, Ozohanics O,
Vekey K, Svergun DI, Borysik AJ, Vertessy BG
Structural model of human dUTPase in complex with a novel
proteinaceous inhibitor
SCIENTIFIC REPORTS 8:(1) Paper 4326. 15 p. (2018)
72: Marton L, Hajdu F, Nagy GN, Kucsma N, Szakacs G,
Vertessy BG
Heterologous expression of CTP:phosphocholine cytidylyltransferase from
Plasmodium falciparum rescues Chinese Hamster Ovary cells deficient in the
Kennedy phosphatidylcholine biosynthesis pathway
SCIENTIFIC REPORTS 8: Paper 8932. 8 p. (2018)
71:
Molnár P, Marton L, Izrael R, Pálinkás HL, Vértessy BG
Uracil
moieties in Plasmodium falciparum genomic DNA
FEBS
OPenbio First Published:27 May 2018 https://doi.org/10.1002/2211-5463.1245872:
70:
Andras Benedek, Istvan Poloskei, Oliver Ozohanics, Karoly Vekey, Beata
G Vertessy
The
Stl repressor from Staphylococcus aureus is an efficient inhibitor of the
eukaryotic fruitfly dUTPase
FEBS
OPEN BIO 8:(2) p. 158167. 10 p. (2018) (címlapábra)
69:
Surányi EV*, Hírmondó R*, Nyíri K, Tarjányi S, Kőhegyi B, Tóth J, Vertessy
BG* (* corr authors)
Exploiting
a phage-bacterium interaction system as a molecular switch to decipher
macromolecular interactions in the living cell
VIRUSES
10:(4) Paper 168. 13 p. (2018)
68: Zsófia Bata, Renzhe Qian, Alexander Roller, Jeannie
Horak, László Csaba Bencze, Csaba Paizs, Friedrich Hammerschmidt, Beáta G
Vértessy*, László Poppe* (* corr author)
A Methylidene Group in Phosphonic Acid Analogue of
Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine
Ammonia-Lyases
ADVANCED SYNTHESIS & CATALYSIS (2017) 359(12):2109-2120.
67: Kenesi E, Carbonell A,
Lózsa R, Vértessy B*, Lakatos L*. (*corr. authors)
A viral suppressor of RNA silencing inhibits ARGONAUTE 1
function by precluding target RNA binding to pre-assembled RISC.
Nucleic Acids Res. 2017 May 12. doi: 10.1093/nar/gkx379.
[Epub ahead of print] PubMed PMID: 28499009.
66: REVIEW: Nyíri K, Vértessy BG.
Perturbation of genome integrity to fight pathogenic
microorganisms.
Biochim Biophys Acta. 2017 Jan;1861(1 Pt B):3593-3612.
65:
Kerepesi C, Szabó JE, Papp-Kádár V, Dobay O, Szabó D, Grolmusz V, Vértessy BG.
Life
without dUTPase.
Front
Microbiol. 2016 Nov 14;7:1768.
64: Lopata A, Leveles I,
Bendes ÁÁ, Viskolcz B, Vértessy BG*, Jójárt B*, Tóth J*. (* corresponding
authors)
A Hidden Active Site in the Potential Drug Target
Mycobacterium tuberculosis dUTPase Is Accessible
through Small Amplitude Protein Conformational Changes.
J Biol Chem. 2016 Dec 16;291(51):26320-26331.
63: Nagy GN, Suardíaz R, Lopata A,
Ozohanics O, Vékey K, Brooks BR, Leveles I, Tóth J, Vértessy BG*, Rosta E*. (*
corresponding authors)
Structural Characterization of Arginine Fingers:
Identification of an Arginine Finger for the
Pyrophosphatase dUTPases.
J Am Chem Soc. 2016 Nov 16;138(45):15035-15045.
62:
Papp-Kádár V, Szabó JE, Nyíri K, Vertessy BG.
In
Vitro Analysis of Predicted DNA-Binding Sites for the Stl Repressor of the
Staphylococcus aureus SaPIBov1 Pathogenicity Island.
PLoS
One. 2016 Jul 7;11(7):e0158793.
61:
Benedek A, Horváth A, Hirmondó R, Ozohanics O,
Békési A, Módos K, Révész Á, Vékey K, Nagy GN, Vértessy BG.
Potential
steps in the evolution of a fused trimeric all-β dUTPase involve a
catalytically competent fused dimeric intermediate.
FEBS
J. 2016 Sep;283(18):3268-86. “Editor’s
Choice”
60:
Pukáncsik M, Orbán Á, Nagy K, Matsuo K, Gekko K, Maurin D, Hart D, Kézsmárki
I, Vertessy BG.
Secondary
Structure Prediction of Protein Constructs Using Random Incremental Truncation
and Vacuum-Ultraviolet CD Spectroscopy.
PLoS
One. 2016 Jun 7;11(6):e0156238.
59: Róna G, Scheer I, Nagy K, Pálinkás HL, Tihanyi G,
Borsos M, Békési A, Vértessy BG.
Detection of uracil within DNA using a sensitive labeling
method for in vitro and cellular applications.
Nucleic Acids Res. 2016 Feb 18;44(3):e28.
58:
Nyíri K, Kőhegyi B, Micsonai A, Kardos J, Vertessy BG.
Evidence-Based
Structural Model of the Staphylococcal Repressor Protein: Separation of
Functions into Different Domains.
PLoS
One. 2015 Sep 28;10(9):e0139086.
57:
Nyíri K, Papp-Kádár V, Szabó JE, Németh V, Vértessy BG
Exploring
the role of the phage-specific insert of bacteriophage Φ11 dUTPase
Structural
Chemistry 2015. 26 (5-6): 1425-1432
56:
Marton L, Nagy GN, Ozohanics O, Lábas A, Krámos
B, Oláh J, Vékey K, Vértessy BG.
Molecular
Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a
Mutant CTP:phosphocholine Cytidylyltransferase
Plos
One, 2015 Jun 17;10(6):e0129632.
55: Hirmondó R, Szabó JE, Nyíri K, Tarjányi S, Dobrotka P,
Tóth J, Vértessy BG.
Cross-species inhibition of dUTPase via the Staphylococcal
Stl protein perturbs dNTP pool and colony formation in Mycobacterium.
DNA Repair (Amst). 2015 Mar 19;30:21-27.
54:
Horváth A, Batki J, Henn L, Lukacsovich T, Róna
G, Erdélyi M, Vértessy BG.
dUTPase
expression correlates with cell division potential in Drosophila melanogaster.
FEBS
J. 2015 Mar 4. doi: 10.1111/febs.13255.
53. Lopata A, Jambrina PG, Sharma PK, BR Brooks BR, Toth J, Vertessy
BG*, Rosta E*. (* corresponding authors)
Mutations decouple proton transfer from phosphate cleavage
in the dUTPase catalytic reaction
ACS Catalysis 2015 Apr 8;5:3225-3237
52:
Róna G, Borsos M, Ellis JJ, Mehdi AM, Christie M, Környei Z, Neubrandt M, Tóth
J, Bozóky Z, Buday L, Madarász E, Bodén M, Kobe B, Vértessy BG.
Dynamics
of re-constitution of the human nuclear proteome after cell division is
regulated by NLS-adjacent phosphorylation.
Cell
Cycle. 2014;13(22):3551-64.
51: “RESPONSE CIKK”: Róna G,
Borsos M, Kobe B, Vértessy BG.
Factors influencing nucleo-cytoplasmic trafficking: which
matter?
Acta Crystallogr D Biol Crystallogr.2014 Oct;70(Pt 10):2777-8.
50: Nagy GN, Marton L,
Contet A, Ozohanics O, Ardelean LM, Révész A,
Vékey K, Irimie FD, Vial H, Cerdan R, Vértessy BG.
Composite aromatic boxes for enzymatic transformations of
quaternary ammonium substrates.
Angew Chem Int Ed Engl. 2014 Dec 1;53(49):13471-6
49:
Róna G, Pálinkás HL, Borsos M, Horváth A, Scheer
I, Benedek A, Nagy GN, Zagyva I, Vértessy BG.
NLS
copy-number variation governs efficiency of nuclear import--case study on
dUTPases.
FEBS
J. 2014 Dec;281(24):5463-78.
48: Szabó JE, Németh V, Papp-Kádár V, Nyíri K, Leveles I,
Bendes AÁ, Zagyva I, Róna G, Pálinkás HL, Besztercei B, Ozohanics O, Vékey K,
Liliom K, Tóth J, Vértessy BG.
Highly potent dUTPase inhibition by a bacterial repressor
protein reveals a novel mechanism for gene expression control.
Nucleic Acids Res. 2014 Oct 29;42(19):11912-20.
47:
Szalkai B, Scheer I, Nagy K, Vértessy BG*, Grolmusz V*.
(* corresponding authors)
The
metagenomic telescope.
PLoS
One. 2014 Jul 23;9(7):e101605.
46:
REVIEW CIKK: Nagy GN, Leveles I, Vértessy BG.
Preventive
DNA repair by sanitizing the cellular (deoxy)nucleoside triphosphate
pool.
FEBS
J. 2014 Sep;281(18):4207-23.
45:
Kovács K, Bánóczi G, Varga A, Szabó I, Holczinger
A, Hornyánszky G, Zagyva I, Paizs C, Vértessy BG*, Poppe L*. (*
corresponding authors)
Expression
and properties of the highly alkalophilic phenylalanine ammonia-lyase of
thermophilic Rubrobacter xylanophilus.
PLoS
One. 2014 Jan 27;9(1):e85943.
44:
Magazu S, Migliardo F, Benedetto A, Vertessy B
Protein
dynamics by neutron scattering: The protein dynamical transition and the
fragile-to-strong dynamical crossover in hydrated lysozyme
CHEMICAL
PHYSICS 424: pp. 26-31. (2013)
43: Róna G, Marfori M, Borsos M, Scheer I, Takács E, Tóth
J, Babos F, Magyar A, Erdei A, Bozóky Z, Buday L,
Kobe B, Vértessy BG.
Phosphorylation adjacent to the nuclear localization signal
of human dUTPase abolishes nuclear import:
structural and mechanistic insights.
Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt12):2495-505.
42: Leveles I, Németh V, Szabó JE, Harmat V, Nyíri K,
Bendes ÁÁ, Papp-Kádár V, Zagyva I, Róna G, Ozohanics O, Vékey K, Tóth J,
Vértessy BG.
Structure and enzymatic mechanism of a moonlighting
dUTPase.
Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2298-308.
41: Barabás O, Németh V, Bodor A,
Perczel A, Rosta E, Kele Z, Zagyva I, Szabadka Z, Grolmusz VI, Wilmanns M,
Vértessy BG.
Catalytic mechanism of α-phosphate attack in dUTPase
is revealed by X-ray crystallographic snapshots of distinct intermediates,
31P-NMR spectroscopy and reaction path modelling.
Nucleic Acids Res. 2013 Dec;41(22):10542-55.
40:
Nagy GN, Marton L, Krámos B, Oláh J, Révész Á, Vékey K, Delsuc F,
Hunyadi-Gulyás É, Medzihradszky KF, Lavigne M, Vial H, Cerdan R, Vértessy
BG.
Evolutionary
and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase
from Plasmodium falciparum.
FEBS
J. 2013 Jul;280(13):3132-48.
39: Horváth A, Békési A, Muha
V, Erdélyi M, Vértessy BG.
Expanding the DNA alphabet in the fruit fly: uracil
enrichment in genomic DNA.
Fly (Austin). 2013 Jan-Mar;7(1):23-7.
38: Muha V, Horváth A, Békési
A, Pukáncsik M, Hodoscsek B, Merényi G, Róna G, Batki J, Kiss I, Jankovics F,
Vilmos P, Erdélyi M, Vértessy BG.
Uracil-containing DNA in Drosophila: stability,
stage-specific accumulation, and developmental involvement.
PLoS Genet. 2012;8(6):e1002738.
37:
Pecsi I, Hirmondo R, Brown AC, Lopata A, Parish
T, Vertessy BG*, Tóth J*. (* corresponding authors)
The
dUTPase enzyme is essential in Mycobacterium smegmatis.
PLoS
One. 2012;7(5):e37461.
36:
Magazù S, Migliardo F, Gonzalez MA, Mondelli C, Parker SF, Vertessy
BG.
Molecular
mechanisms of survival strategies in extreme conditions.
Life
(Basel). 2012 Dec 7;2(4):364-76.
35:
Poppe L, Paizs C, Kovács K, Irimie FD, Vértessy B.
Preparation
of unnatural amino acids with ammonia-lyases and 2,3-aminomutases.
Methods
Mol Biol.2012;794:3-19.
34:
Leveles I, Róna G, Zagyva I, Bendes Á, Harmat V, Vértessy BG.
Crystallization
and preliminary crystallographic analysis of dUTPase from the φ11 helper
phage of Staphylococcus aureus.
Acta
Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt
11):1411-3.
33: Pécsi I, Szabó JE, Adams SD, Simon I, Sellers JR,
Vértessy BG*, Tóth J*. (* corresponding authors)
Nucleotide pyrophosphatase employs a P-loop-like motif to
enhance catalytic power and NDP/NTP discrimination.
Proc Natl Acad Sci U S A.
2011 Aug 30;108(35):14437-42.
32:
Merényi G, Kovári J, Tóth J, Takács E, Zagyva I, Erdei A, Vértessy
BG.
Cellular
response to efficient dUTPase RNAi silencing in stable HeLa cell lines perturbs
expression levels of genes involved in thymidylate metabolism.
Nucleosides
Nucleotides Nucleic Acids. 2011 Jun;30(6):369-90.
31:
Bozóky Z, Róna G, Klement É, Medzihradszky KF, Merényi G, Vértessy BG*, Friedrich
P*. (* corresponding authors)
Calpain-catalyzed
proteolysis of human dUTPase specifically removes
the
nuclear localization signal peptide.
PLoS
One. 2011;6(5):e19546.
30: Erdélyi P, Borsos E, Takács-Vellai K, Kovács T, Kovács
AL, Sigmond T, Hargitai B, Pásztor L, Sengupta T, Dengg M, Pécsi I, Tóth J,
Nilsen H, Vértessy BG*, Vellai T*. (* corresponding authors)
Shared developmental roles and transcriptional control of
autophagy and apoptosis in Caenorhabditis elegans.
J Cell Sci. 2011 May 1;124(Pt
9):1510-8.
29:
Bekesi A, Pukancsik M, Haasz P, Felfoldi L,
Leveles I, Muha V, Hunyadi-Gulyas E, Erdei A, Medzihradszky KF, Vertessy
BG.
Association
of RNA with the uracil-DNA-degrading factor has major conformational effects
and is potentially involved in protein folding.
FEBS
J. 2011 Jan;278(2):295-315.
28: REVIEW: Vértessy BG, Orosz F.
From "fluctuation fit" to "conformational
selection": evolution, rediscovery, and integration of a concept.
Bioessays. 2011 Jan;33(1):30-4.
27: Horváth A, Vértessy BG.
A one-step method for quantitative determination of uracil
in DNA by real-time PCR.
Nucleic Acids Res. 2010 Nov;38(21):e196.
26: Pecsi I, Leveles I, Harmat V, Vertessy BG*, Toth J*.
(*corresponding authors)
Aromatic stacking between nucleobase and
enzyme promotes phosphate ester hydrolysis in dUTPase.
Nucleic Acids Res. 2010 Nov;38(20):7179-86.
25:
Takács E, Nagy G, Leveles I, Harmat V, Lopata A,
Tóth J, Vértessy BG. Direct contacts between conserved motifs of
different subunits provide major contribution to active site organization in
human and mycobacterial dUTPases.
FEBS
Lett. 2010 Jul 16;584(14):3047-54.
24:
Merényi G, Kónya E, Vértessy BG.
Drosophila
proteins involved in metabolism of uracil-DNA possess different types of
nuclear localization signals.
FEBS
J.2010 May;277(9):2142-56.
23:
Pukáncsik M, Békési A, Klement E, Hunyadi-Gulyás
E, Medzihradszky KF,
Kosinski
J, Bujnicki JM, Alfonso C, Rivas G, Vértessy BG.
Physiological
truncation and domain organization of a novel uracil-DNA-degrading factor.
FEBS
J. 2010 Mar;277(5):1245-59.
22:
Takács E, Barabás O, Petoukhov MV, Svergun DI, Vértessy BG.
Molecular shape and prominent role of beta-strand swapping in organization of
dUTPase oligomers.
FEBS
Lett. 2009 Mar 4;583(5):865-71.
21:
Muha V, Zagyva I, Venkei Z, Szabad J, Vértessy BG.
Nuclear
localization signal-dependent and -independent movements of Drosophila
melanogaster dUTPase isoforms during nuclear cleavage.
Biochem
Biophys Res Commun. 2009 Apr 3;381(2):271-5.
20: REVIEW: Vértessy BG, Tóth J.
Keeping uracil out of DNA: physiological role, structure
and catalytic mechanism of dUTPases.
Acc Chem Res. 2009 Jan 20;42(1):97-106.
19:
Varga B, Barabás O, Takács E, Nagy N, Nagy P, Vértessy BG.
Active
site of mycobacterial dUTPase: structural characteristics and a built-in
sensor.
Biochem
Biophys Res Commun. 2008 Aug 15;373(1):8-13.
18:
Kovári J, Barabás O, Varga B, Békési A, Tölgyesi
F, Fidy J, Nagy J, Vértessy BG.
Methylene
substitution at the alpha-beta bridging position within the phosphate chain of
dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
Proteins.
2008 Apr;71(1):308-19. PubMed PMID: 17932923.
17:
Varga B, Barabás O, Kovári J, Tóth J, Hunyadi-Gulyás E, Klement E,
Medzihradszky KF, Tölgyesi F, Fidy J, Vértessy BG.
Active
site closure facilitates juxtaposition of reactant atoms for initiation of
catalysis by human dUTPase.
FEBS
Lett. 2007 Oct 2;581(24):4783-8. Epub 2007 Sep 12.
16: Tóth J, Varga B, Kovács M, Málnási-Csizmadia A, Vértessy BG.
Kinetic mechanism of human dUTPase, an essential nucleotide
pyrophosphatase enzyme.
J Biol Chem. 2007 Nov 16;282(46):33572-82.
15:
Békési A, Pukáncsik M, Muha V, Zagyva I, Leveles
I, Hunyadi-Gulyás E, Klement E, Medzihradszky KF, Kele Z, Erdei A, Felföldi F,
Kónya E, Vértessy BG.
A
novel fruitfly protein under developmental control degrades uracil-DNA.
Biochem
Biophys Res Commun. 2007 Apr 13;355(3):643-8.
14: Németh-Pongrácz V, Barabás O, Fuxreiter M, Simon I,
Pichová I, Rumlová M, Zábranská H, Svergun D, Petoukhov M, Harmat V, Klement E,
Hunyadi-Gulyás E, Medzihradszky KF, Kónya E, Vértessy BG.
Flexible segments modulate co-folding of dUTPase and
nucleocapsid proteins.
Nucleic Acids Res. 2007;35(2):495-505.
13:
Németh-Pongrácz V, Snasel J, Rumlova M, Pichova I, Vértessy BG.
Interacting
partners of M-PMV nucleocapsid-dUTPase.
Nucleosides
Nucleotides Nucleic Acids.
2006;25(9-11):1197-200.
PubMed PMID: 17065090.
12:
Barabás O, Németh V, Vértessy BG.
Crystallization
and preliminary X-ray studies of dUTPase from Mason-Pfizer monkey retrovirus.
Acta
Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt
4):399-401.
11:
Kovári J, Imre T, Szabó P, Vértessy BG.
Mechanistic
studies of dUTPases.
Nucleosides
Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1475-9.
10: Barabás O, Pongrácz V, Kovári J, Wilmanns M, Vértessy
BG.
Structural insights into the catalytic mechanism of
phosphate ester hydrolysis by dUTPase.
J Biol Chem. 2004 Oct 8;279(41):42907-15. “Paper
of the week”
9:
Takács E, Grolmusz VK, Vértessy BG.
A
tradeoff between protein stability and conformational mobility in homotrimeric
dUTPases.
FEBS
Lett. 2004 May21;566(1-3):48-54. PubMed PMID:
15147867.
8: Békési A, Zagyva I,
Hunyadi-Gulyás E, Pongrácz V, Kovári J, Nagy AO, Erdei A, Medzihradszky KF,
Vértessy BG.
Developmental regulation of dUTPase in Drosophila
melanogaster.
J Biol Chem. 2004 May 21;279(21):22362-70.
Epub 2004 Mar 2. PubMed
7: Kovári J, Barabás O, Takács E, Békési A, Dubrovay Z,
Pongrácz V, Zagyva I, Imre T, Szabó P, Vértessy BG.
Altered active site flexibility and a structural
metal-binding site in eukaryotic dUTPase: kinetic characterization, folding,
and
crystallographic studies of the homotrimeric Drosophila
enzyme.
J Biol Chem. 2004 Apr 23;279(17):17932-44.
Epub 2004 Jan 14. PubMed PMID: 14724274.
6: Dubrovay Z, Gáspári Z, Hunyadi-Gulyás E, Medzihradszky
KF, Perczel A,
Vértessy BG.
Multidimensional NMR identifies the conformational shift
essential for catalytic competence in the 60-kDa Drosophila melanogaster
dUTPase trimer.
J Biol Chem. 2004 Apr 23;279(17):17945-50.
Epub 2004 Jan 14. PubMed PMID: 14724273.
5: Barabás O, Rumlová M, Erdei A, Pongrácz V, Pichová I, Vértessy BG. dUTPase and
nucleocapsid polypeptides of the Mason-Pfizer monkey virus form a fusion
protein in the virion with homotrimeric organization and low catalytic
efficiency.
J Biol Chem. 2003 Oct 3;278(40):38803-12.
Epub 2003 Jul 16. PubMed PMID: 12869552.
4: Mustafi D, Bekesi A,
Vertessy BG*, Makinen MW*. (* corresponding authors)
Catalytic and structural role of the metal ion in dUTP
pyrophosphatase.
Proc Natl Acad Sci U S A.
2003 May 13;100(10):5670-5. Epub 2003 Apr 29. PubMed
PMID: 12721364; PubMed Central PMCID: PMC156259.
3:
Fiser A, Vértessy BG.
Altered
subunit communication in subfamilies of trimeric dUTPases.
Biochem
Biophys Res Commun. 2000 Dec 20;279(2):534-42. PubMed
PMID:
11118321.
2: Vertessy
BG*, Larsson G, Persson T, Bergman AC, Persson R, Nyman PO. The complete
triphosphate moiety of non-hydrolyzable substrate analogues is required for a
conformational shift of the flexible C-terminus in E. coli dUTP
pyrophosphatase. (* corresponding author)
FEBS
Lett. 1998 Jan 2;421(1):83-8. PubMed PMID: 9462846. -
címlapábra
1: Vertessy
BG.
Flexible
glycine rich motif of Escherichia coli deoxyuridine triphosphate
nucleotidohydrolase is important for functional but not for structural
integrity of the enzyme. Proteins. 1997 Aug;28(4):568-79.
PubMed PMID: 9261872.